3rd International Congress on Recent Innovations in Engineering, Science and Technology - Istanbul - Turkey (2022-06-24)

Modeling of diffusion of polyphenols into different media
Diffusion plays a crucial role especially for determination of extraction conditions, of drug release processes and functional food development. Whereas, in the ?ndustry, the diffusion coefficient varies according to the composition of the material or materials and the conditions of the extraction processes, if the solvent is body fluid the main variables affecting on it is different (the pH value of the environment, the interaction of the ion type with diffused material). Determining the effect of the variables on the diffusion coefficient provides to make a decision whether efficiency enhance approaches (mixing, temperature etc.) are necessary compared to their costs, but also in determining the required amount or releasing time in the production of medicine or food. In order to construct a base point of all, extraction of polyphenols from pomegranate flowers were modelled in this paper. Water and methanol were chosen as samples of industrial solvents and three simulated media (gastric fluid and intestines) were used to observe the diffusion into the human body. Molecular diffusions were followed with time at four positions, spectrophotomerically. Page, Logarithmic and Peleg Model equations and Fick’s law were applied in modelling and compared. Molecular diffusion in methanol was found independent of position but dependent of time, and very low compared to the water. It was concluded that to obtain dried polyphenols, the cheapest method would be methanolic extraction without mixing. In the simulated fluids, the acidity found to have a significant role on diffusion.
Assist. Prof. Sibel Y?g?tarslan, Mrs. Tugce Ozkaya