International Congress on Recent Innovations in Engineering, Science and Technology - Istanbul - Turkey (2019-10-31)

Using MOFs and MOFs composite to enhance the solubility of class II drugs
In this work MOFs HKUST-1 and a new composite material consisting of a model MOFs (HKUST-1) and graphite oxide was successfully synthesized and tested as a drug delivery vehicle. Three BCS Class II drugs felodipine, ketoprofen, and ibuprofen were used as the model drugs. The adsorption of those three drugs on-to the surface of HKUST-1/GO (graphite oxide), HKUST-1 and graphite oxide was compared. Due to the molecules size of the drug it was found that the ability of drug loading for ibuprofen is higher than the other two drugs, what is more, the addition of GO enhanced both drug loading and the specific surface area which can be explained by the hydrogen bonding between GO and the drugs. Drug release experiments were also conducted, and it was found the solubility of the drugs were all improved
Mr. Jinyang Han, Dr. Chirangano Mangwandi