5TH International Congress on Technology - Engineering & Science - Kuala Lumpur - Malaysia (2018-02-01)

Formulation, Evaluation And Optimization Of Metronidazole Sr Buccal Tablet For Gingivitis Using Artificial Intelligence

Gingivitis is a condition that require sustained concentration of antibiotic locally for extended period of time. The current study aimed to formulate and evaluate the sustained and localized action of metronidazole (MTZ) as mucoadhesive buccal tablet containing Hydroxypropylmethyl cellulose (HPMC), Carbopol 940® (CP), carboxymethylcellulose (CMC) and ethyl cellulose (EC) as mucoadhesive polymers. Tablets were compressed using different proportions of polymeric blend (F1-F16) and evaluated in terms of mucoadhesive physicochemical properties. Results indicated that tablet weight variation (249+2.10mg) and friability (0.21%) were within USP specifications. Maximum mucoadhesive strength and mucoadhesive time were depicted by F1 and F14 which were 28.47g and 12hr respectively. All formulations were within physiological limit of pH, except F4. Maximum swellability index was exhibited by F16 which was 261.9% (8 hr) containing highest amount of HPMC used. For in vitro release, the pre-set 8 hr complete release were shown only by formulations, F15 and F16 which were 100.7 % and 96 % respectively. Genetic algorithm was applied on the attributes obtained in above results to optimize ingredients for desirability. The software predicted polymer concentration was then tested (F17) for stated tests. The weight variation (248 ±2.11mg) and friability (0.32%) results complied with USP standards. DD solver® was employed on release data to evaluated mode of release. Results suggested that Korsmeyer-Peppas model diffusion mode of MTZ release from polymeric matrix. Thus, optimized formulation (F17) containing CP (16.4mg), HPMC (78.7mg), CMC (8.3mg) and EC (10.5mg) released MTZ more than 96% up to 6 hr.
Sobia Razzaq, Sana Hanif, Javed Iqbal, Saeed ul Hassan, Ikramullah Khan, Muhammad Ali Syed