4TH International Congress on Technology - Engineering & SCIENCE - Kuala Lumpur - Malaysia (2017-08-05)

Novel α-hydroxy[1-(2-ethoxyethyl) Piperidin-4-yl]phosphonate As Candidate For Multi-purpose Substances

Research is to develop methods of construction of novel synthetic molecules, "working" on the principle of natural enzymes and/or phytohormones, i.e. in low concentrations, significantly reducing the risk of negative impact on the living organism or plant. The combination of the piperidine moiety and the phosphonate group is quite popular due to the good "pharmacophore" of both structures. Numerous studies have shown that organic phosphonates have the potential antibacterial, anticancer, antimicrobial and antithrombotic properties. Furthermore, the phosphonate moiety can readily form complexes with metal ions. Aminopolyphosphonates as multidentate complexing agents are used in medicine to relieve metal overload in living organisms. The applicability of complexes for treating anemia of iron overload in the body is known. For a purpose to search of novel biological active of wide spectra of action molecules of wide spectra of action there were used set of interrelated studies: Chemical stage included a serial circuit of a fine organic synthesis techniques from starting molecules to the metal complexes, having a moiety of N-(2-ethoxyethyl)piperidine, phosphonate fragment, and ion of biogenic metal; Biological stage was composed of evaluation of biological properties synthesized systems. Therefore the first part of this research includes the synthesis, identification of N-(2-ethoxyethyl)piperidin hydroxyphosphonate (II), in a concentration of 10-3 % stimulating growth and resistance to drought of plants, and in the experiment on animals poisoned with salts of heavy metals, this preparation increases their immune status. But the second part is devoted to the study of their use as complexation II with biogenic metal ions (III).
N Kystaubayeva, K Praliyev, T Iskakova, El-Sayed Negim, T Seilkhanov,