4TH International Congress on Technology - Engineering & SCIENCE - Kuala Lumpur - Malaysia (2017-08-05)

Targeted Doxorubicin Delivery To Bearst Cancer Cells
Doxorubicin (DOX) is one of the anticancer agents. When free-DOX is injected into the blood vessels, not only the cancer cells but also the healthy cells were affected. The free-DOX was encapsulated within liposomes in order to safely deliver it to the tumour site with long circulation times within the body. However, the DOX-loaded liposomes were accumulated within the capillaries causing wounds and scarfs especially at the finger tips and foots, which were called as hand-and-foot syndrome. Therefore, the chemotherapy become painful during the cancer treatment. One method to overcome this problem could be attaching the DOX loaded liposomes to microbubbles, target them to the specific markers, and deliver the drug directly to the tumour site. In this talk, we introduced some of our findings such that DOX was encapsulated within the liposomes, coupled to microbubbles as the ultrasound contrast agents, delivered to the tumour site formed from the breast cancer cells within nude mice, visualized the microbubbles on the tumour, and effectively delivered the drug to the tumours under ultrasound. This project was supported by the Scientific and Technological Research Council of Turkey (TUBITAK) through the grant numbers of 213M668.
Sevgi KILIC OZDEMÄ°R, Ekrem OZDEMIR, Mustafa BARIS, Osman YILMAZ, Safiye AKTAS,