3RD INTERNATIONAL CONGRESS ON TECHNOLOGY - ENGINEERING & SCIENCE - Kuala Lumpur - Malaysia (2017-02-09)

Cardioprotective Effect Of Avena Sativa Linn. In Isoproterenol Induced Myocardial Infarction In Rats
The objective of study was to evaluate the cardioprotective effect of Avena sativa Linn. (Figure 1) in Isoproterenol (ISO) induced myocardial infarction in rats. The myocardial infarction in Albino Wistar rats was induced by ISO (dose 5.25 on 11th and 8.5 mg/kg s.c. on 12th day) [1]. Three different doses (125, 250 and 500 mg/kg) of alcoholic extract of Avena sativa seeds (AEASS) were prepared corresponding to body weight of animals [2]. Rats were pretreated with AEASS (125, 250 and 500 mg/kg/day, oral) for period of 10 days and ISO was injected on 11th and 12th day. After 24 hours blood was collected through retero-orbital plexus for the estimation of biochemical parameters and histopathological studies were also performed. TTC staining was done to evaluate infarct size in heart. The administration of AEASS significantly lowered the level of the lactate dehydrogenase (LDH), creatinine phosphokinase (CK-MB), (Table 1) alkaline phosphatase (ALP), TBARS levels and increased GSH level as well as significantly changed haemodynamic parameters in the ISO Induced myocardial necrosis. The integrity of the myocardial cell membrane and inflammatory cell infiltration and reduced muscle separation were promptly improved in the histopathological studies of the ISO-induced myocardium. It could be due to the antioxidant activity and restoration of myocardial biomarkers demonstrating the cardioprotective activity of the AEASS. The effect of climatic conditions on the chemical constituents responsible for the cardioprotective activity can also be explored.
Harmanpreet Kaur, Kumar Gaurav Singhal, Monika Gupta