5TH International Congress on Technology - Engineering & Science - Kuala Lumpur - Malaysia (2018-02-01)

Copper(ii), Palladium(ii) And Zinc(ii) Complexes Of O^o And N^s Donor Ligands As Anticancer Agents

A series of divalent copper, palladium and zinc complexes of O^O and N^S donor ligands are synthesized and characterized by using different spectroscopic (FT-IR, UV-visible, 1H, 13C NMR, EPR) and analytical techniques (LC-MS, HRMS, TGA). The free ligands L1 and the N^S donor substituted thiophene-2-carboxaldehyde thiosemicarbazones (L3-L5) and the copper(II) complexes, [Cu(L1)2.2MeOH] are unambiguously characterized by single crystal X-ray diffraction studies. DFT calculations for the thiophene thiosemicarbazones ligands (L3-L5) have given a correlation with the experimental results. Involvement of solvent methanol molecules in to the coordination was seen after crystallization of the copper complex, extending the four coordinated square planar geometry around the copper(II) ion to six coordinated tetragonal geometry. The synthesized molecules are screened for their antimicrobial potential against gram –ve bacteria like E. coli and P. aeruginosa and gram +ve bacteria like S. aureus and S. pneumonia. The complexes are tested for cytotoxicity against the normal 3T31 pancreatic adipocytes. Cytoxicity of the compounds was observed at 500 μM concentrations. Anticancer activity of the complexes of O^O and N^S donor ligands have shown potential against the Human Breast Cancer cell line MDA-MB-231.
JAGADEESH MAHIMALURU, LAVANYA M, VARADA REDDY AMMIREDDY