5TH International Congress on Technology - Engineering & Science - Kuala Lumpur - Malaysia (2018-02-01)

Comparative Efficacy Of Different Indigenous Drugs Against Paramphistomosis From Pakistan

The paramphistomicidal activity of four indigenous drugs including Nigella sativa seeds, Fumaria parviflora aerial parts, Caesalpinia crista seeds and Saussurea lappa roots with allopathic drug oxyclozanide (allopathic) in one hundred and fifty buffaloes was calculated in fifteen controlled experiments against paramphistomosis. Efficacy was determining by observing the difference in eggs per gram faeces (EPG) and clinical performance of the animals pre and post treatment, Nigella sativa, after a single dose of 30, 40 and 50 mg/kg body mass, reduced EPG by 65.85, 68.29 and 71.79 per cent, respectively. After the second dose the respective reduction in EPG was 85.36, 92.68 and 94.87per cent respectively. Fumaria parviflora at a single dose of 30, 40 and 50 mg/kg body mass were 46.34, 53.65 and 59.52 percent, respectively, whereas efficacy at two dose levels with the same dose rate was 82.92, 90.24 and 92.85 percent, respectively. Caesalpinia crista at 30, 40 and 50mg/kg body mass were 47.61, 52.63 and 64.1 percent, respectively at one dose level and was 80.95, 86.84 and 92.3 percent, respectively. Saussurea lappa at a rate of 30, 40 and 50 mg/kg body mass was 50, 53.48 and 56.09 percent effective, respectively at one does level and was 71.42, 81.39 and 85.36 percent effective at two dose levels. Oxyclozanide at one dose level at a rate of 10mg/kg body mass was 66.66 per cent effective and at two dose levels it was 97.43 per cent effective. The efficacy order was Oxyclozanide, Nigella sativa, Fumaria parviflora, Caesalpinia crista and Saussurea lappa. No side effects were noted due to the use of any of these plant-origin drugs.
Umbreen Javed Khan, Tanveer Akhtar, Azhar Maqbool, Ghazalah Yasmin