4TH International Congress on Technology - Engineering & SCIENCE - Kuala Lumpur - Malaysia (2017-08-05)

The Synthesis Of Clopidogrel

Cardiac and cerebrovascular disease is a common disease.It is well recognized that antiplatelet agent is effective in the prevention and treatment of thrombosis.Clopidogrel is one of thieno pyridine derivatives,which can inhibit ADP-induced platelet aggregation. The preparation methods of Clopidogrel were reviewed and Clopidogrel was finally synthesized from 2-chlorobenzyl cyanide via bromination,condensation,hydrolyze,esterification ,resolution,Finally with the sulfate, re-crystallization product of the target compound clopidogrel.The overall yield is 16%. Synthesis of the intermediate product and finally the structure of the product through ESI and 1H-NMR corroboration.The improved synthetic procedure has the advantage of low cost and is suitable for industrial production.
huang yuanjun