4TH International Congress on Technology - Engineering & SCIENCE - Kuala Lumpur - Malaysia (2017-08-05)

The Synthesis Of Clopidogrel

Cardiac and cerebrovascular disease is a common disease．It is well recognized that antiplatelet agent is effective in the prevention and treatment of thrombosis．Clopidogrel is one of thieno pyridine derivatives，which can inhibit ADP-induced platelet aggregation. The preparation methods of Clopidogrel were reviewed and Clopidogrel was finally synthesized from 2-chlorobenzyl cyanide via bromination，condensation，hydrolyze，esterification ，resolution，Finally with the sulfate, re-crystallization product of the target compound clopidogrel．The overall yield is 16%. Synthesis of the intermediate product and finally the structure of the product through ESI and 1H-NMR corroboration.The improved synthetic procedure has the advantage of low cost and is suitable for industrial production．
huang yuanjun